Peptides research

CJC-1295 and Ipamorelin — the science behind GHRH and ghrelin receptor synergy

CJC-1295 and Ipamorelin act on different receptor classes — GHRH-R and the ghrelin receptor — to amplify the natural pulsatile growth hormone pulse. This article covers how the two mechanisms complement each other and why the combination produces cleaner GH release than either compound alone.

Research peptides: complete guide to mechanisms, categories, and evidence

A comprehensive reference covering all major categories of research peptides: tissue repair, cognitive enhancement, metabolic regulation, longevity, and mitochondrial function. Covers mechanisms, evidence quality, regulatory status, and cross-category comparisons.

KPV — the tripeptide anti-inflammatory derived from alpha-MSH

KPV is the C-terminal tripeptide of alpha-MSH with potent anti-inflammatory activity through NF-κB inhibition and MC1R activation. This article covers the inflammatory cascade it targets, its bioavailability relative to full-length MSH, and the gut epithelium research.

Dihexa: hepatocyte growth factor signalling and synaptic potentiation

Dihexa (PNB-0408) is a small peptide derived from angiotensin IV that potentiates hepatocyte growth factor (HGF) signalling at the MET receptor, driving synaptogenesis and cognitive enhancement in preclinical models. This review covers its mechanism, evidence base, and research context.

PT-141 and the melanocortin pathway — receptor pharmacology of bremelanotide

PT-141 (bremelanotide) activates melanocortin receptors in the central nervous system to produce arousal effects independent of vascular mechanisms. This article covers the MC3R and MC4R pharmacology, the hypothalamic circuit involved, and how this differs from phosphodiesterase inhibitors.

Thymosin beta-4 (TB-500): mechanisms of tissue repair and regeneration

TB-500 is a synthetic analogue of thymosin beta-4, a ubiquitous actin-sequestering peptide involved in cell migration, wound healing, and angiogenesis. This review covers the mechanistic evidence for its regenerative effects.

BPC-157 tissue repair mechanisms — what the receptor pharmacology actually says

BPC-157 is a stable gastric pentadecapeptide with documented effects on tendon, muscle, gut, and nerve tissue. This breakdown covers the growth factor receptor interactions, nitric oxide pathway involvement, and what the preclinical data means for repair protocols.

What are research peptides — a plain-language mechanistic overview

Research peptides are short amino acid chains that act as signalling molecules. This overview covers how they differ from proteins, how they reach their target receptors, and why structural specificity determines biological effect.