Anti-aging research
Anti-aging
Longevity research, epigenetic clocks, telomere biology, and anti-aging peptide science.
Ashwagandha: Clinical Evidence for Cortisol, Testosterone, and Adaptogenic Mechanisms
Ashwagandha (Withania somnifera) has accumulated strong clinical trial evidence for cortisol reduction, testosterone support, and stress adaptation. This practitioner-level review covers mechanisms, trials, dosing, and safety.
Rhodiola Rosea for Fatigue and Mental Performance: Clinical Evidence Review
Rhodiola rosea (Arctic root) modulates the stress response via salidroside and rosavins. This review covers clinical trial data on fatigue, cognitive performance, cortisol, and exercise adaptation.
Autophagy, Fasting, and Longevity: A Naturopathic Clinical Framework
A clinician-to-patient framework covering autophagy mechanisms (mTOR/AMPK), types (macroautophagy, mitophagy), fasting protocols (16:8, 24h, 5:2), autophagy-inducing compounds (spermidine, resveratrol, berberine), and clinical cautions — for naturopathic practice.
Growth hormone secretagogues — pulsatile GH release, IGF-1, and the anti-ageing evidence base
Growth hormone secretagogues stimulate endogenous pulsatile GH release rather than replacing it, preserving the physiological pulse architecture that exogenous GH overrides. This article covers somatotroph biology, the IGF-1 axis, the difference between secretagogue and exogenous GH pharmacology, and what the longevity and body composition data shows.
Epigenetic clocks and peptide interventions — what biological age measurement tells us about repair protocols
Epigenetic clocks measure biological age through DNA methylation patterns at specific CpG sites, and several peptide interventions have produced measurable clock reversals in preclinical and early clinical research. This article covers how the Horvath, GrimAge, and DunedinPACE clocks work, what they measure, and what the Yamanaka factor and peptide intervention data means for ageing biology.
Yamanaka factors and partial reprogramming: resetting the epigenetic clock
Partial cellular reprogramming using Yamanaka factors (Oct4, Sox2, Klf4, c-Myc) transiently reverses epigenetic age in somatic cells without inducing pluripotency. This review examines the mechanistic basis, key experimental findings, and the distinction between full and partial reprogramming.
Senolytic peptides and cellular senescence: targeted clearance of ageing cells
Cellular senescence — the irreversible arrest of damaged cells — drives tissue inflammation and age-related pathology through the SASP. This review examines peptide-based senolytic strategies targeting senescent cell survival pathways.
GHK-Cu — the copper tripeptide and its collagen, wound healing, and anti-inflammatory mechanisms
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is an endogenous tripeptide that declines with age and activates over 4,000 genes involved in collagen synthesis, wound repair, anti-inflammatory signalling, and antioxidant defence. This article covers the copper binding chemistry, the TGF-β and decorin pathway interactions, and the skin and wound healing data.